Researchers at the University Medical Center Eppendorf in Hamburg are developing custom 3D printed tablets tailored for children, particularly those undergoing chemotherapy. This innovative approach aims to create palatable, easy-to-swallow medications that meet the unique needs of young patients. The study, set to conclude by 2026, focuses on simplifying dosage and improving medication acceptance. The 3D printing process produces visually appealing tablets, potentially benefiting both pediatric and adult patients with swallowing difficulties.
Revolutionizing Medication: Custom 3D Printed Tablets for Children
Imagine a world where medications are personalized, created specifically for individual needs. Researchers at the University Medical Center Eppendorf (UKE) in Hamburg are pioneering this concept with innovative 3D printing technology that allows for the production of tailored drug dosages.
For over three years, UKE’s pharmacy team has been dedicated to developing this groundbreaking method. The result? A specialized 3D printer capable of crafting medications that cater specifically to young patients, particularly those facing severe health challenges. Claudia Langebrake, the research group leader, highlights the unique needs of pediatric medicine, stating, “We are producing medications for children as part of our ongoing study. Many medications can be unpalatable and difficult for children to swallow, especially when they are too large or taste bitter.”
Research Study Set to Conclude by 2026
The goal of this initiative is straightforward: to simplify the medication process for critically ill children. Pharmacist Adrin Dadkhah and Langebrake are currently printing Dexamethasone, a vital medication for children undergoing high-dose chemotherapy. This treatment is essential in preventing severe nausea and ensuring that children can retain food, which is crucial for their health during such challenging times.
The ongoing study, which commenced recently and is projected to conclude by the end of 2026, will see children receive standard tablets during their first chemotherapy session and custom 3D printed chewable tablets in their subsequent treatment cycle. This approach focuses on improving medication acceptance and safety, as emphasized by Langebrake.
The 3D printed tablets have a chewy texture, similar to gummy bears, making them easier for children to consume.
Custom Dosage Solutions
Dexamethasone is available in adult dosages, often necessitating complex adjustments for pediatric patients. Parents frequently face the daunting task of halving, quartering, and weighing tablets to ensure accurate dosing based on their child’s weight. Pediatric oncologist Alexander von Hugo, who is leading the study at UKE, notes the emotional strain this places on families, underscoring the critical need for customized medications.
Many traditional tablets are not only difficult to dose accurately but also have unpleasant tastes or sizes that make swallowing a challenge for young patients. This innovative printing technology aims to resolve those issues by creating precisely tailored tablets that are both palatable and easy to consume.
Innovative Printing Process
The 3D printing process is fascinating: pharmacist Dadkhah prepares a large syringe filled with a vibrant red substance containing Dexamethasone and various additives that ensure even distribution and the desired texture. “We refer to our mixture as printer ink, which includes the active ingredient and excipients, all meticulously balanced to achieve the right consistency,” he explains. The mixture is heated within the print head, allowing it to liquefy and be shaped into three-dimensional tablets—whether in hearts, stars, or classic round forms.
The resulting tablets are soft yet not mushy, resembling gummy candies, and are designed to be visually appealing and aromatic, with a raspberry scent that encourages children to take their medications without resistance.
Broadening Applications Beyond Pediatrics
Von Hugo expresses his enthusiasm for the potential of this technology, stating, “If this initiative is successful, it would represent a significant breakthrough in pediatric medicine. Being able to create the exact dosage in an easy-to-consume format for at-home use would be a tremendous advantage.”
Moreover, the potential applications extend beyond pediatric patients. This approach could be beneficial for adults struggling with similar issues, such as those with Parkinson’s or dementia, who often face difficulties in swallowing their medications.
This groundbreaking research not only opens doors for individual patient care but also signifies a new era in pharmaceutical innovation.