Leylah Fernandez was beaten 6-4, 6-4 by defending Indian Wells champion Paula Badosa on Tuesday.
The Spaniard reached the quarter-finals after an hour and 45 minutes.
The 18th-seeded Fernandez was broken three times including the fifth game of the second set, where she erased a 0-40 deficit.
Fifth seed Badosa overcame seven double faults, including one in the final game.
After that, she added a winner and then ended the match with a cross shot, which Fernandez failed to bring back into play.
The 19-year-old Lavalloise came to California having triumphed in Mexico the previous week.
Aged 24, Badosa will next face Veronika Kudermetova, 24th in the world.
Third-seeded Iga Swiatek prevailed 4-6, 6-2, 6-3 over Angelique Kerber. Polish, Swiatek triumphed at Roland-Garros in 2020.
In doubles, Gabriela Dabrowski and Giuliana Olmos advanced to the semi-finals, winning 6-2, 2-6 and 10-7 ahead of Romania’s Irina Camelia-Begu and Monica Niculescu. The Canadian-Mexican pair got the job done in 77 minutes. Dabrowski and Olmos are the fifth seeds.
Dabrowski’s compatriot, Denis Shapovalov and the Indian Rohan Bopanna lost their flag against the Mexican Santiago Gonzalez and the Frenchman Édouard Roger-Vasselin, 4-6, 6-4 and 4-10.
Shapovalov and his partner shone with 10 aces against just one for their rivals, but they also committed nine double faults, six more than their opponents.
Gonzalez and Roger-Vasselin will face Russians Aslan Karatsev and Andrey Rublev in the quarter-finals.